Concerning the mechanisms by which S63845/SCH772984 induced apoptosis in melanoma cells, we found strong indications of an activation of intrinsic proapoptotic pathways, namely loss of mitochondrial membrane potential, cytochrome c release, as well as caspase-9 and caspase-3 activation, in both BRAF-mutated and WT cells. The gene discussed is CYCS; the disease is melanoma.