- The reduction of Bcl-2, which is a regulatory factor that promotes or inhibits apoptosis, and increased activity of caspase-3, which is an active factor in the end process of apoptosis, stimulate the apoptosis of colon cancer cells; - Sericin damages cancer cells, causes morphological changes, encourages cell shrinkage, and induces nuclear condensation. The gene discussed is BCL2; the disease is colonic neoplasm.