Defects in the 30 shared genes are related to several pathologies, such as vision abnormalities (TMEM135) [60], cancer (CDH6 [49], FZD10 [48], TIAM2 [47]), neuropsychiatric disorders (Tenm4 [51], Pde4dip [52], Grid2 [78]), deafness (TFB1M) [55], neutrophil disorders (VPS45) [74] and others. Here, VPS45 is linked to cancer.