Similarly, treatment of the RCC Caki-1 cell line with Sunitinib in vitro increased the expression of GRP78, which can in turn lead to increased proliferation of the renal cancer cells in hypoxic/hypoglycemic stress situations and confer resistance to apoptosis by stimulating the PERK/eIF2α signaling axis [166]. This evidence concerns the gene EIF2AK3 and renal cell carcinoma.