Importantly, autophagy represents an important mechanism involved in the initiation and progression of RCC by allowing cells to recycle their intracellular materials/organelles to promote proliferation (as observed, for example, in vitro in Caki RCC cells, in which p53 is degraded in autophagic vesicles, favoring rapid proliferation of renal cancer cells [113,114]). The gene discussed is TP53; the disease is renal cell carcinoma.