For example, the gene coding for IRE1α (ERN1) was shown to be frequently mutated (increased copy number) and to contribute to breast cancer malignancy, with a specific subtype of breast cancer (luminal B breast cancer) showing the strongest ERN1 gene gain/amplification frequency, over 68%, as observed through in silico assessment of the Pan-Cancer Atlas of The Cancer Genome Atlas (TCGA) [138]. Here, ERN1 is linked to breast cancer.