As mentioned, Sunitinib was also described to activate the IRE1α and the PERK branches of the UPR in vitro in 786-O RCC cells, therefore increasing the expression of NF-kB, as well as those of the pro-inflammatory cytokines Il-6, Il-8 and TNFα [47]. This evidence concerns the gene EIF2AK3 and renal cell carcinoma.