Integrated multi-omics analysis of human ccRCC samples revealed that (i) NDUFA4L2 targeted by HIF1 triggers mitochondrial dysfunction and blockage of mitochondrial respiration through inhibition of the Complex I of the respiration chain [28]; (ii) HIF1 interactor MUC1 regulates glycogen degradation, glycolysis, PPP, TCA cycle in RCC [29]; and (iii) HIF1-mediated transcription of PFKFB4 promotes PPP activation in RCC [30,31]. The gene discussed is SETD2; the disease is renal cell carcinoma.