PLIN2 and nonpapillary renal cell carcinoma: Supporting an aberrant accumulation of lipids in ccRCC cells, analysis of early stage human ccRCC revealed an increased expression of the lipid transporter CD36, the lipid synthesis enzymes SCD1 and ELOVL2, and the structural component of lipid droplets PLIN2, as well as downregulation of ANXA3, a negative regulator of lipid accumulation [21,33].