This combination effectively induced ER stress (observed through GRP78 upregulation), histone acetylation and, to a great extent, cell death of RCC, both in vitro in 769-P, 786-O, Caki-2 RCC cells and in vivo in a xenograft mouse model of subcutaneous grafting of Caki-2 cells. The gene discussed is HSPA5; the disease is renal cell carcinoma.