The importance of GRP78 in Sunitinib resistance was also demonstrated in vivo in the same study, where xenografting of Caki-1 cells lacking the expression of GRP78 in nude mice resulted in significantly lower tumor growth, compared to Caki-1 cells expressing GRP78, when the mice were treated with Sunitinib [166]. The gene discussed is HSPA5; the disease is neoplasm.