Indeed, analyses of the TCGA-KIRC cohort of ccRCC patients via the Gepia2 cancer database (RCC biopsies of the patients) showed that VHL and PBRM1 expressions correlate with ERN1, EIF2AK3 and ATF6, whereas BAP1 does not correlate with any of the ER stress mediators (Figure 4). This evidence concerns the gene ERN1 and renal cell carcinoma.