HSPA5 and renal carcinoma: Simultaneous treatments of Fluvastatin (statin-inhibiting cholesterol synthesis) and Vorinostat (histone deacetylase inhibitor) further resulted in decreased renal cancer growth in vitro in ACHN, A498 and Renca cells and in vivo in an allograft model of Renca subcutaneous injection in nude mice, through cooperative induction of histone acetylation and ER stress induction (detected as GRP78 upregulation) [150].