BRCA1 and malignant colon neoplasm: ATF6 was shown to sustain the expression of oncogenes such as BRCA1 or CIP2A (in vitro data in human colon cancer cell lines CaCO2, and SW480), as well as prevent DNA damage and to improve cancer cell viability, as observed in RKO and HCT116 colon cancer cell lines [145,146].