SPHK1 and cancer: Taking into consideration the cancer development process, the following histaminergic genes stood out: GNA15, HRH1-HRH4, MAOA, WASF2, along with inflammation-related genes: AEBP1, CXCL1, CXCL2, CXCL3, CXCL8, SPHK1, and TNFAIP6.