The expression of BAX and E-cadherin was upregulated and the expression of α-SMA, collagen I, Bcl-2, CDK2, CDK4, Cyclin D1, N-cadherin, Vimentin, Snail, WNT-1, and β-catenin was downregulated in BPH rats treated with SV. The gene discussed is CDK4; the disease is benign prostatic hyperplasia.