TYR and vitiligo: As for humoral immunity, patients with vitiligo were found to have elevated serum titers of antibodies directed against melanocytes (e.g., anti-MelanA, anti-Melanin Concentrating Hormone Receptor 1 (MCHR1), anti-tyrosinase, anti-gp100, and anti-tyrosine hydroxylase) that do not correlate with vitiligo activity, and they cannot be considered the main driver of vitiligo pathogenesis [70].