STAT3 and colonic neoplasm: Different signaling pathways affected by FA2H over-expression have been identified: a higher chemosensitivity in gastric cancer cells depends on the inhibition of the mTOR/S6K1/Gli1 pathway by FA2H (through activation of AMPK) [137]; FA2H suppresses cancer stemness by inhibiting STAT3 and NF-κB signaling (through reduced phosphorylation of STAT3 and NF-κB) [144] and FA2H reduces metastasis in colon cancer through phosphorylation and the cytosolic retention of the transcription factor YAP1 [140].