As a result, the majority of the top 20 individual genes identifying critical COVID-19 patients with more severe disease were derived from the Inflammatory Neutrophil module (CARD16, CAST, CD177, FKBP5, H2BC21, HIF1A, MCEMP1, NT5C3A) as well as genes from the IFN (EIF2AK2, SP100), Unfolded Protein (DERL1, ERAP1, SSR1), AA Metabolism (OXCT1), and T-cell-related modules (CCR2, CD28, CREM, EOMES, SGK1) (Figure 4D and Figure S3B, Table S3). This evidence concerns the gene SP100 and COVID-19.