In this context, we conclude: (1) that the activity of initiation factors is essential, both for NAFLD evolution to HCC and for HCC progression, marking an evident difference between HCCs driven by viral infection and HCCs driven by lipid accumulation, and (2) eIF6 is the only translation factor consistently upregulated through the transition from NAFLD to HCC, and then, HCC progression. The gene discussed is EIF6; the disease is metabolic dysfunction-associated steatotic liver disease.