Leptin levels were determined in 287 pre-pubertal children (mean age 8.09 years), classified as follows: ASD with overweightness/obesity (ASD+/Ob+); ASD without overweightness/obesity (ASD+/Ob−); non-ASD with overweightness/obesity (ASD−/Ob+); non-ASD without overweightness/obesity (ASD−/Ob−). Here, LEP is linked to obesity disorder.