A study by Sadagurski et al. [45] reported an increased nuclear accumulation of FoxO1 and the expression of SOD2 and PPARGC1A, FoxO1-dependent genes, in the brains of R6/2 diabetic mice with increased insulin receptor substrate 2 levels; these mice had slower progression of HD symptoms [45]. The gene discussed is SOD2; the disease is Huntington disease.