The extract derived from CV, besides anti-proliferative and cytotoxic activity, also has anti-migratory and anti-invasive potentials against numerous tumor cells, including triple-negative breast cancer [98,142], estrogen receptor (ER)-positive breast cancer [91], colon cancer [129,130], pancreatic and gastric cancer [143], and melanoma [144]. This evidence concerns the gene ESR1 and breast cancer.