Corroborating our findings, a previous study showed that a high level of CDX1 expression and less invasive and aggressive phenotype was associated with a higher abundance of multifucosylation on N-glycans in the CRC cell lines and was supported by the upregulation of GTs involved in antenna fucosylation such as FUT3/5/6 (Figure 5) [16,71], Taking into account the previous and current findings, we hypothesize that CDX1 may play an essential role in the formation of (s)Le antigens on colon-like cell lines via the regulation of the corresponding GTs (mainly FUT3/6). Here, FUT3 is linked to colorectal carcinoma.