PPARG and obesity due to melanocortin 4 receptor deficiency: At the molecular level, Tencerova et al. [38] found upregulated mRNA levels of adipogenic genes (e.g., PPARγ, leptin (LEP), adiponectin) in BMSCs of obese mice compared with BMSCs of lean mice, which indicates that obesity drives BMSCs toward adipogenic lineage commitment [38].