At the molecular level, Tencerova et al. [38] found upregulated mRNA levels of adipogenic genes (e.g., PPARγ, leptin (LEP), adiponectin) in BMSCs of obese mice compared with BMSCs of lean mice, which indicates that obesity drives BMSCs toward adipogenic lineage commitment [38]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.