When human ALOX15 was overexpressed in the intestinal epithelium under the control of the villin promoter [66], the resulting transgenic mice were protected from the development of azoxymethane-induced colonic tumors, and expression of the ALOX15 transgene was always impaired in tumor cells when compared with non-tumor controls [67]. The gene discussed is ALOX15; the disease is colonic neoplasm.