Despite the interesting finding that VCAM-1 expression in HSCs was enhanced during NASH, HSC-specific VCAM-1 deficient mice did not display any differences in steatosis, inflammation and fibrosis, compared to the control mice, as assessed by histology, flow cytometry and gene expression studies in the HCD-induced model. The gene discussed is VCAM1; the disease is metabolic dysfunction-associated steatohepatitis.