However, the MMP-8 levels were lower at all the analyzed time-points of the orthodontic treatment when compared with those detected during periodontitis: 1 week (1970.41 pg/mL, p = 0.011), 1 month (2013.12 pg/mL, p < 0.040), 3 months (1996.23 pg/mL, p = 0.045), 6 months (1951.11 pg/mL, p = 0.042), 12 months (1887.88 pg/mL, p = 0.047), 18 months (1828.26 pg/mL, p = 0.001), and 24 months (1675.53 pg/mL, p < 0.001) (Figure 6a). The gene discussed is MMP8; the disease is periodontitis.