In the present study, the levels of different pro-inflammatory and pro-destructive mediators common between periodontitis and orthodontics were quantified, and it was shown that the levels of the RANKL, OPG, IL-6, IL-17A, and MMP-8 do not vary during the 2 years of orthodontic treatment. The gene discussed is TNFRSF11B; the disease is periodontitis.