During periodontitis, the RANKL levels detected in the vestibular periodontal site (331.64 pg/mL) were significantly higher than those detected in the palatine (240.88 pg/mL, p = 0.017), distal (249.21 pg/mL, p = 0.025), and mesial (251.76 pg/mL, p = 0.031) sites (Figure 1b). The gene discussed is TNFSF11; the disease is periodontitis.