Recent reports have also shown that HDAC3 expression and activity are associated with the expression of several AD-related genes, pro-inflammatory TNF-α and IL-6 and GFAP [40], while the neuroprotective effect of HDAC3 inhibitor (RGFP966) on modulating neuronal memory [55] and extensive neurite outgrowth [56] increases histone H3 and H4 acetylation, reducing Aβ expression and the level of tau phosphorylation [21]. This evidence concerns the gene TNF and Alzheimer disease.