AIF1 and Alzheimer disease: In this study, we found that the number of amyloid plaques consistent with IBA1-positive microglia and GFAP-positive astrocytes gradually increased from 3 to 8 months, confirming that Aβ plaques and the activation of microglia and astrocyte are closely associated in the studied region of the entorhinal cortex in AD (Figure 1 and Figure 2).