In fact, our data suggest that PARP-1 only exerts detrimental activities in patients harbouring tumours with wtp53, but a high PARP-1 expression in mutated p53 tumours seems to be beneficial as it is an independent prognostic factor for survival, and these differences may be a result of a differential regulation of CSCs by PARP-1 depending on p53. This evidence concerns the gene TP53 and neoplasm.