Similarly, patients with chronic obstructive pulmonary disease supplemented with saffron crocus (30 mg/day of crocin during 12 weeks) demonstrated decreased serum levels of total oxidative status and NF-κB, which indicated that saffron supplementation appears to effectively establish oxidant/antioxidant balance and improve inflammatory conditions in patients with COPD [171]. The gene discussed is NFKB1; the disease is chronic obstructive pulmonary disease.