In order to predict the risk of liver carcinogenesis in Japanese patients with hepatitis B, we constructed a prediction model by adding HLA to items that had been incorporated into previous HBV related HCC prediction models, including basic information (including sex, year of birth, and age at first year registration) and blood test results (including HBV-DNA levels, presence or absence of HBe antigen, serum ALT level, platelet counts, serum albumin level, and AFP level). This evidence concerns the gene AFP and hepatitis B virus infection.