INS and obesity due to melanocortin 4 receptor deficiency: After stratification by obesity status, blood hemoglobin (r = −0.36, p = 0.019), haematocrit (r = −0.44, p = 0.003) and ultrasensitive CRP (r = −0.37, p = 0.016) were significantly associated with the change in insulin sensitivity in subjects without obesity.