In order to select the manuscripts, we proceeded to search on PubMed and Web of Science using the following keywords “miRNAs” and “MAPK” or “map kinase” and “or “p38” or “jnk” or “ERK” and “Alzheimer’s disease”; publications ranging from 2010 to 2023 were selected. The gene discussed is MAPK1; the disease is Alzheimer disease.