In order to select the manuscripts, we proceeded to search on PubMed and Web of Science using the following keywords “miRNAs” and “MAPK” or “map kinase” and “or “p38” or “jnk” or “ERK” and “Alzheimer’s disease”; publications ranging from 2010 to 2023 were selected. Here, MAPK1 is linked to early-onset autosomal dominant Alzheimer disease.