APLN and hypertensive disorder: As expected, based on the endothelium-dependent vasodilative properties of apelin, different isoforms of this peptide were demonstrated to mitigate hypertension in in vivo models, with apelin-12 exhibiting the greater effect on blood pressure lowering after intraperitoneal injection of apelin-12, apelin-13, and apelin-36 in anesthetized rats.