The activation of the brain-derived neurotrophic factor (BDNF)-Tyrosine Kinase receptor B (TrkB) signaling pathway, and the inhibition of the NF-κB pathway and endoplasmic reticulum (ER) stress-associated AMPK/TXNIP/NLRP3 inflammasome are other targets of apelin-mediated suppression of neuroinflammation, resulting in improvement of cognitive dysfunction, depressive-like behavior, and early brain injury subarachnoid hemorrhage [142,146,147]. Here, BDNF is linked to subarachnoid hemorrhage.