APLN and ischemic stroke: In an in vivo model of ischemic stroke, apelin-13 reduced the expression of pro-inflammatory cytokines and chemokines (IL-1β, TNF-α, macrophage inflammatory protein 1α or MIP-1α, monocyte chemoattractant protein 1 or MCP-1) produced by M1 microglia and increased the expression of the M2-derived anti-inflammatory cytokine IL-10 [144].