TP53 and hepatocellular carcinoma: Evidence of Aurora-A/c-Myc binding is controversial, since it was reported that no binding between the two proteins occurs in liver and hepatocellular carcinoma cells [112], while on the other hand, Aurora-A and the double-phosphorylated c-Myc co-immunoprecipitated in TP53-altered (deleted or mutated) HCC cells [107].