In a particular case, an increased Myc transcription activity was observed: in B cell lymphoma, the SUMOylation mediated by the E3 ligase PIAS1 allows the recognition and phosphorylation of Myc in S62 by JNK1, which precludes the oncoprotein degradation [31]. This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.