Injection of a splicing-MOs directed against gba1, the zebrafish ortholog of the human GBA1 gene, caused the appearance of specific alterations in 5 dpf embryos, including curvature of the trunk, defects of primary bone ossification with a decrease in col10a1 and runx2b gene expression associated with a dysfunction of the osteoblast population, and severe erythropenia and thrombocytopenia caused by early hematopoietic defects. Here, GBA1 is linked to Thrombocytopenia.