TCF7L2, HHEX, KCNJ11, CENTD2, ARAP1, FTO, HNF1B, PPARG, IGF2BP2, CDKAL1, VEGFA, SLC30A8, CDKN2A, CDKN2B, KCNQ1, UBE2E2, ANK1, ABCC8, IRS1, and GLP2R are the genes whose polymorphic variants showed strong associations with susceptibility to T2D and related phenotypes [134,135,136]. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.