CypA/CD147 activation induces CSC features in breast cancer cells through the STAT3 and solute carrier family 34 member 2 (SLC34A2)/phosphatidylinositol-3-kinase (PI3K)/AKT/SRY-box transcription factor 2 (SOX2) signaling pathways [15,32]. This evidence concerns the gene AKT1 and breast cancer.