Cyclophilin A and CD147 are overexpressed in various types of cancers, and CypA/CD147 interaction can activate multiple oncogenic signaling pathways, including phosphatidylinositol-3-kinase (PI3K)/AKT and MAPKs, thereby promoting the proliferation, anti-apoptosis, metastasis, angiogenesis, drug resistance, and stemness of cancer cells [10,16,28]. Here, PPIA is linked to cancer.