As a critical component of a membrane repair complex, dysferlin is hypothesized to orchestrate sealing of membrane defects in muscles, with dysferlin mutation and consequent dysfunction giving rise to limb girdle muscular dystrophy type 2B (also called LGMD R2 dysferlin-related [1]). Here, DYSF is linked to autosomal recessive limb-girdle muscular dystrophy type 2B.