Recently, an article has reviewed the PTMs of mitochondrial proteins that were the components of mPTP [27], such as cyclophilin D (CYPD), VDAC, the FoF1 ATP synthase complex (FoF1 ATPase), adenosine nucleotide translocase (ANT), CK, phosphate carrier (PIC), hexokinase (HK) and the 18 kDa translocator protein (TSPO), and the relation of these PTMs (phosphorylation, acetylation, oxidation and oxidative PTMs (S-nitrosylation, S-glutathionylation, nitration, deamination and ubiquitylation)) to cardiac diseases. The gene discussed is SLC25A3; the disease is heart disorder.