KLRK1 and vitiligo: Interestingly, a transcriptome analysis performed on paired lesional and non-lesional skin biopsies from vitiligo patients and normal skin biopsies from healthy volunteers showed that 17 genes are downregulated (which are mostly related to the melanogenesis process), such as TYRP1, TYR, MLANA, and TRPM1, and 13 genes upregulated, most of which are implicated in innate and acquired immune cells, such as NK and CD8+ T cells, and are KLRC1, KLRC2, NKG2D (KLRK1), KLRG1, and others [117].