Indeed, melanocyte stress induces MICA and MICB molecules, i.e., NKG2DLs, that interact with NKG2D on CD8+ T cells, and this process is thought to be crucial in the development of vitiligo [124] because of results from a mouse model in which NKG2DL expression on target cells is sufficient to induce vitiligo [122]. This evidence concerns the gene MICA and vitiligo.