SP1 and metabolic dysfunction-associated steatotic liver disease: These authors have shown that genetic polymorphism in the gene regulatory region of PON1 (rs705379:C  >  T) contributes to NAFLD pathogenesis by increasing the SP1-mediated promoter occupancy leading to hypomethylation and PON1 expression and simultaneous SREBP-2 upregulation-mediated cholesterol accumulation in the liver [151].