Hepatic expression of KLF11 was reduced in both these models, while overexpression of KLF11 in HFD-fed mice and in db/db mice prevented the development of fatty liver via induction of PPARα-mediated expression of fatty acid oxidation genes, such as Cpt1a, Mcad, Cyp4a10, and Cyp4a14 [81]. The gene discussed is KLF11; the disease is fatty liver disease.