With a system biology approach applied to human liver transcriptomic datasets to identify the gene co-regulatory networks and transcriptional regulation in a disease state, it was identified that KLF13 is one of the most significantly enriched transcription factors associated with NAFLD disease pathogenesis along with SREBF2, HNF4A, SREBF1, and YY1. The gene discussed is SREBF2; the disease is metabolic dysfunction-associated steatotic liver disease.