In contrast to these findings, RNA interference against KLF6 in HepG2 and HuH7 cells caused upregulation of pro-apoptotic p53 and inhibited anti-apoptotic Bcl-xL expression, implicating the possible importance of KLF6 for HCC cells to evade apoptosis [170]. This evidence concerns the gene KLF6 and hepatocellular carcinoma.