PFKFB3 and hepatocellular carcinoma: SP1 has also been identified to possibly regulate the F-type specific mRNA transcription of a bifunctional enzyme, 6-phosphofructo-2-kinase (PFK2)/fructose-2,6-bisphosphatase (FBPase2), that catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a stimulator of glycolysis in rat hepatoma cells [70].