A comprehensive literature search using PubMed and Google Scholar for studies published between 1990 and 2022 was performed using ‘tocilizumab’; ‘sarilumab’; or ‘interleukin-6′ and one of the following search terms: ‘macular edema’, ‘diabetic retinopathy’, ‘uveitis’, ‘macular degeneration’, ‘autoimmune retinopathy’, and ‘retinal vein occlusion’. This evidence concerns the gene IL6 and diabetic retinopathy.