IL6 and juvenile idiopathic arthritis: TNF-alpha inhibitors are often regarded as first-line biologic therapy in NIU refractory to steroids and conventional immunosuppressive medications such as methotrexate, mycophenolate, and cyclosporine [6] However, when first-line therapies fail, IL-6 inhibitors are integral in treatment-resistant NIU, particularly in the setting of uveitis secondary to JIA.