Herein, to verify whether the expression of inflammasome components could be altered by Sézary syndrome, we assessed the expression of NLRP1, NLRP3, AIM2, IL-1B and IL-18 by immunohistochemistry in the epidermal and dermal layers of skin from SS patients (Figure 1 and Supplementary Materials Figure S1). This evidence concerns the gene NLRP1 and Sezary syndrome.