NFKB1 and osteoarthritis: Taking into consideration that osteoarthritis might be related to AGE, it was shown that salicin inhibited AGE formation in human SW1353 chondrosarcoma cells as well as AGE-induced expression and secretion of TNF-α, IL-1β, MCP-1, and HMGB-1 through the inhibition of the AGE-induced activation of NF-κB.