NFKB1 and colorectal cancer: Silibinin was found to inhibit the activation of NF-κB by inhibition of IκBα, p50, or p65 phosphorylation in different cell types such as HMC-1 human mast cells, RANKL-induced RAW264.7 cells, colorectal cancer cells, and LO2 cells in vitro, as well as in monocytes from preeclamptic women ex vivo [132,158,159,160,161,162].