Since mitochondrial dysfunction and oxidative stress have been shown to contribute to nigrostriatal degeneration in PD patients and in animal models of PD [40,41], our current results indicate that this DJ-1-upregulating efficacy of RNS60 may participate in RNS60-mediated protection of the nigrostriatum in a mouse model of PD. The gene discussed is PARK7; the disease is Parkinson disease.