Valcarce and colleagues [111] studied the effect of sperm cryopreservation on six genes with roles in fertilization and embryo development (BIK, FSHB, PRM1, ADD1, ARNT and PEG1/MEST) and two genome regions related to Prader–Willi and Angelman syndrome (UBE3A and SNORD116/PWSAS). Here, MEST is linked to Angelman syndrome.