In cases of chronic hyperglycemia seen in T2DM, AGEs are further generated by interacting with RAGE receptors, prompting the activation of various intracellular erythrogenic pathways such as the nuclear factor-kappa B (NF-κB) and proinflammatory mediators such as IL-6, TNF-α, and C-reactive protein (CRP) [19,54,55]. The gene discussed is TNF; the disease is type 2 diabetes mellitus.