In another study utilizing a triple transgenic AD (3xTg-AD) mouse model, a 3-month treatment with quercetin reduced extracellular β-amyloidosis and enhanced microglial and astroglial activation in the brain, as evidenced by diminished levels of Aβ1-40, Aβ1-42, and BACE1-mediated cleavage of APP [118]. This evidence concerns the gene APP and Alzheimer disease.