Dysregulation of NaV1.5 has been reported in various cardiac channelopathies such as prolonged QT syndrome, Brugada syndrome, idiopathic ventricular fibrillation, and arrhythmogenic right ventricular cardiomyopathy (ARVC) [18,19]. The gene discussed is SCN5A; the disease is Arrhythmogenic right ventricular dysplasia.