In particular, the immune–histological analysis evidenced that chemokine C-X-C motif receptor 4 (CXCR4) and 12 (CXCR12) have pivotal roles in induced hypoxia, leading to both tubulointerstitial fibrosis and glomerulosclerosis in NAS [16]. The gene discussed is CXCR4; the disease is glomerulosclerosis.