Concerning the use of probiotics in patients affected by spondyloarthritis, two studies affirmed no significant decrease in any disease activity markers such as the Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), ASAS-endorsed core domains, global health status, and CRP after probiotic intervention compared with a placebo (p > 0.05) [134,135]. Here, CRP is linked to spondylitis.