It should be noted that several studies [127,128,129,130,131,132,133,134,135,136,137] showed that the administration of specific probiotics (E. faecium, L. casei, L. plantarum, B. longum, Bifidobacteria, P. histicola, L. acidophilus, L. helveticus, B. adolescentis, and L. fermentum) may reduce RA symptoms by increasing anti-inflammatory cytokines (i.e., IL-10 and TGF-β) and inhibiting pro-inflammatory cytokines (i.e., IL-1β, IL-2, IL-6, IL-12, IL-17, and NF-κB), thus promoting the differentiation of CD4+ T cells into regulatory T cells (Tregs). This evidence concerns the gene IL6 and rheumatoid arthritis.