CCL2 and rheumatoid arthritis: In accordance with this result, Pineda et al. [133] showed a non-significant decreasing trend in serum levels of IL-1α, IL-6, IL-10, IL-12, TNF-α, and Monocyte chemoattractant protein-1 (MCP-1) following L. rhamnosus combined with L. reuteri treatment in RA patients.