APP and Alzheimer disease: Our results in the 12-month-old APP/PS1 mice are in line with these data, since despite an evident decrease in total protein levels, the proportion of putative synaptic localized receptor subunits in the analyzed layers of CA1 and DG were not altered in comparison to WTs, altogether indicating that the changes in the expression levels of GlyRs in AD should primarily involve the extrasynaptic localized GlyR subunits.