The role of IFN-γ in cutaneous sarcoidosis is reinforced by the observation that IFN-γ-inducible chemokines CXCL9 and CXCL10 are elevated in serum and tissue of patients with systemic sarcoidosis, and blood transcriptional profiles show IFN-γ-related signaling pathways in such patients [51,52]. This evidence concerns the gene IFNG and skin sarcoidosis.