In this study, the expression of adiponectin in adipose tissues of KK/Ay mice, which showed suppression of type 2 diabetes mellitus by oral LPS administration, was increased, and the adiponectin receptor, a molecule in the pathway for adiponectin to induce increased the gene expression levels of insulin signaling-related factors, was also upregulated (Figure 6). This evidence concerns the gene INS and diabetes mellitus.