Associations between imaging features and the mutational status of ccRCC identified that poor edges of the tumor and calcifications are associated with the BAP1 mutation [214] and predict the RUNX3 methylation level [224], and well-defined tumor edges are associated with the VHL mutation [204], as well as the m1 mutation subtype and the less accurate m3 subtype, which is negatively associated with well-defined margins [215]. This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.