COXFA4L2 and nonpapillary renal cell carcinoma: In particular, in ccRCC, we observe a metabolic reprogramming characterized by an anaerobic switch that induces the rerouting of sugar metabolism toward the pentose phosphate pathway (with the aim of promoting both nucleotide biosynthesis and redox homeostasis) and impairs the mitochondrial activity through the overexpression of NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 (NDUFA4L2) [146,147,148].