On the other hand, mice carrying a mutation of the gene encoding vascular endothelial growth factor (VEGF) developed an ALS-like phenotype, and transcriptomic analysis showed a massive downregulation of numerous genes linked to crucial mechanisms, including synaptic functions, axonogenesis, axonal transport, and growth factor signaling pathways, thus impairing plastic changes in a pathogenic context requiring plasticity and triggering neurodegeneration [77]. The gene discussed is VEGFA; the disease is amyotrophic lateral sclerosis.