However, autoptic examination of brains of individuals with ALS/FTD caused by the C9orf72 mutation demonstrated hippocampal sclerosis in a number of cases [102] and TDP-43 proteinopathy in many CNS areas, including the neocortex, lower motor neurons, and hippocampus [103]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.