Moreover, the accumulation of neurotrophin in muscles of ALS patients could suggest an attempt to support motor unit function, although inefficient [84], and the higher expression of VEGF and nerve growth factor receptors in the NMJ of extraocular motor units can partially support the resistance of extraocular MNs to neurodegeneration in ALS [110,112]. This evidence concerns the gene NGFR and amyotrophic lateral sclerosis.