Many other factors interact with TDP-43, including, for example, the molecular chaperone Cyclophilin A and the mitochondrial protein CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10), and their alterations can drive TDP-43 proteinopathy and synaptic defects similar to those caused by alterations of TDP-43 itself, including a reduction in synaptic proteins and hippocampal LTP together with motor unit loss [56,64]. The gene discussed is TARDBP; the disease is proteostasis deficiencies.