In the somatic and mitotic clusters, the upregulated genes in BSA–BSB and the downregulated genes in BSB–NBS were significantly enriched in Pathways in cancer, Focal adhesion, Relaxin signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, ECM-receptor interaction, Hippo signaling pathway, and AGE-RAGE signaling pathway in diabetic complications. The gene discussed is RENBP; the disease is cancer.