Plasma concentrations of Apo A-I, Apo A-II, Apo A-IV, Apo C-I, Apo C-II, Apo D, Apo H, Apo J, Apo M and LCAT were significantly reduced in COVID-19 patients, whereas the Apo E concentration was increased in these patients. The gene discussed is CLU; the disease is COVID-19.