Given that the lipid profile is profoundly affected in COVID-19, we quantified 14 apolipoproteins (Apo (a), Apo A-I, Apo A-II, Apo A-IV, Apo B100, Apo C-I, Apo C-II, Apo C-III, Apo D, Apo E, Apo H, Apo J, Apo L1 and Apo M) and lecithin-cholesterol acyltransferase (LCAT) by mass spectrometry in the plasma of 44 COVID-19 patients and sex matched controls. This evidence concerns the gene APOC3 and COVID-19.