HK2 and osteosarcoma: Moreover, the inhibition of miRNA21 was also correlated with the suppression of the Warburg effect in the osteosarcoma MG-63 cell line, through the reduction of the levels of lactic acid, adenosine triphosphate (ATP), and glucose uptake, and the downregulation of those proteins involved in the Warburg effect, such as GLUT1, lactate dehydrogenase A (LDHA), hexokinase 2 (HK2), and pyruvate kinase M1/2 (PKM) [102].